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Finding: This meta-analysis demonstrates that perioperative GLP-1RAs increased the rate of GI symptoms and the risk of elevated residual gastric content, improved glycemic control, and did not change the rates of hypo or hyperglycemia, postoperative inotropic support, PONV, atrial fibrillation, and 30-day mortality

2,5,7,8,13 Exercise Physical activity enhances GLP-1 secretion and incretin sensitivity through improved L-cell responsiveness and metabolic signaling

However, sustainable clinical weight loss is a steady progression, with most individuals seeing measurable and significant changes in scale weight and body composition within 4 to 12 weeks of consistent treatment

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